abstract:Neuromuscular-blocking drugs block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. This is accomplished either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release or by acting postsynaptically at the acetylcholine receptors of the motor nerve end-plate.
A non-depolarizingneuromuscularblocking drug (e. g., vecuronium, atracurium, orpancuronium) can be substituted forsuccinylcholine, buttheonsetof paralysis is delayed byabout 60seconds.